The growing capabilities of Large Language Models (LLMs) show significant potential to enhance healthcare by assisting medical researchers and physicians. However, their reliance on static training data is a major risk when medical recommendations evolve with new research and developments. When LLMs memorize outdated medical knowledge, they can provide harmful advice or fail at clinical reasoning tasks. To investigate this problem, we introduce two novel question-answering (QA) datasets derived from systematic reviews: MedRevQA (16,501 QA pairs covering general biomedical knowledge) and MedChangeQA (a subset of 512 QA pairs where medical consensus has changed over time). Our evaluation of eight prominent LLMs on the datasets reveals consistent reliance on outdated knowledge across all models. We additionally analyze the influence of obsolete pre-training data and training strategies to explain this phenomenon and propose future directions for mitigation, laying the groundwork for developing more current and reliable medical AI systems.

Large language models (LLMs) often retain outdated or incorrect information from pre-training, which undermines their reliability. While model editing methods have been developed to address such errors without full re-training, they frequently suffer from knowledge conflicts, where outdated information interferes with new knowledge. In this work, we propose Conflict-free Model Editing (CoME), a novel framework that enhances the accuracy of knowledge updates in LLMs by selectively removing outdated knowledge. CoME leverages unlearning to mitigate knowledge interference, allowing new information to be integrated without compromising relevant linguistic features. Through experiments on GPT-J and LLaMA-3 using Counterfact and ZsRE datasets, we demonstrate that CoME improves both editing accuracy and model reliability when applied to existing editing methods. Our results highlight that the targeted removal of outdated knowledge is crucial for enhancing model editing effectiveness and maintaining the model's generative performance.

The dynamic nature of knowledge in an ever-changing world presents challenges for language models trained on static data; the model in the real world often requires not only acquiring new knowledge but also overwriting outdated information into updated ones. To study the ability of language models for these time-dependent dynamics in human language, we introduce a novel task, EvolvingQA, a temporally evolving question-answering benchmark designed for training and evaluating LMs on an evolving Wikipedia database. The construction of EvolvingQA is automated with our pipeline using large language models. We uncover that existing continual learning baselines suffer from updating and removing outdated knowledge. Our analysis suggests that models fail to rectify knowledge due to small weight gradients. In addition, we elucidate that language models particularly struggle to reflect the change of numerical or temporal information. Our work aims to model the dynamic nature of real-world information, suggesting faithful evaluations of the evolution-adaptability of language models.